NLRC4 polyclonal antibody
产品名称： NLRC4 polyclonal antibody
英文名称： NLRC4 polyclonal antibody
产品编号： PAB12895
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NLRC4.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human NLRC4.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- A 110 KDa band can be detected. Ipaf antibody is human specific.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES.J Biol Chem. 2001 Jul 27;276(30):28309-13. Epub 2001 Jun 4.
- 2.
- Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.
Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J.Biochem Biophys Res Commun. 2001 Jun 1;284(1):77-82.
- 3.
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.Cell. 1997 Nov 14;91(4):479-89.
- Entrez GeneID:
- 58484
- Protein Accession#:
- NP_067032
- Gene Name:
- NLRC4
- Gene Alias:
- CARD12,CLAN,CLAN1,CLANA,CLANB,CLANC,CLAND,CLR2.1,IPAF
- Gene Description:
- NLR family, CARD domain containing 4
- Omim ID:
- 606831
- Gene Ontology:
- Hyperlink
- Gene Summary:
- In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM
- Other Designations:
- ICE-protease activating factor,NOD-like receptor C4,caspase recruitment domain family, member 12,caspase recruitment domain protein 12,nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
- Related Disease