Anti-Jak1 Monoclonal Antibody
品牌：solarbio | 货号：K001410M
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K001410M-50ul
solarbio
50ul
960.00元
K001410M-100ul
solarbio
100ul
1600.00元

英文名称
Anti-Jak1 Monoclonal Antibody
别名
JAK1A;JAK1B;JTK3
应用
WB IF IP
稀释比例
WB 1:1000. IHC 1:200.
交叉反应
Human Rat
蛋白分子量
130kDa
Gene ID
3716
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法
Saturated ammonium sulfate precipitation
亚型
IgG2a
免疫原
Purified recombinant human Jak1 protein fragments expressed in E.coli.
性状
液体
Public Immunogen Range
Purified recombinant human Jak1 protein fragments expressed in E.coli.
Subcellular Locations
Endomembrane system Peripheral membrane protein
Swiss Prot
P23458
克隆号
8B8-E7-G3
克隆类型
Monoclonal Antibody
背景资料
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.