KCNQ1 monoclonal antibody, clone S37A-10
产品名称： KCNQ1 monoclonal antibody, clone S37A-10
英文名称： KCNQ1 monoclonal antibody, clone S37A-10
产品编号： MAB6654
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant KCNQ1.
- Immunogen:
- Recombinant fusion protein corresponding to amino acids 2-101 of human KCNQ1.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- Detects ~75KDa.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-10 ug/mL)
Immunohistochemistry (0.1-1.0 ug/mL)
Immunocytochemistry (0.1-1.0 ug/mL)
Immunofluorescence (1.0-10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Congenital long QT syndrome.
Crotti L, Celano G, Dagradi F, Schwartz PJ.Orphanet J Rare Dis. 2008 Jul 7;3:18.
- 2.
- Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.Cell. 2004 Oct 1;119(1):19-31.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of human cell line mixed lysate with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
- Western Blot (Transfected lysate)
- Western blot analysis in mink-KvLQT1 transfected CHO cell with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
- Immunohistochemistry
- Immunohistochemical staining of mouse brain tissue with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
- Entrez GeneID:
- 3784
- Protein Accession#:
- P51787
- Gene Name:
- KCNQ1
- Gene Alias:
- ATFB1,FLJ26167,JLNS1,KCNA8,KCNA9,KVLQT1,Kv1.9,Kv7.1,LQT,LQT1,RWS,SQT2,WRS
- Gene Description:
- potassium voltage-gated channel, KQT-like subfamily, member 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- Jervell and Lange-Nielsen syndrome 1,kidney and cardiac voltage dependend K+ channel,long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1,slow delayed rectifier channel subunit
- Gene Pathway
- Related Disease
- Arrhythmia
- Arrhythmias, Cardiac
- Asymptomatic Diseases
- Atrial Fibrillation
- Atrioventricular Block
- Birth Weight
- Bradycardia
- Brugada Syndrome
- Cadaver
- Carcinoma
- Cardiomyopathies
- Cardiovascular Diseases
- Channelopathies
- Chromosome Deletion
- Coronary Artery Disease
- Death, Sudden
- Death, Sudden, Cardiac
- Diabetes Complications
- Diabetes Mellitus